We will realize a precision medicine through innovative diagnostics technologies.
Gene analysis technologies have made rapid advances. In particular, the innovation of next-generation DNA sequencing has brought about dramatic progress in genetic research into cancer. New discoveries of genetic changes in cancer are soon expected to reveal the mechanisms by which cancer develops and progresses.
Among our current research, Project HOPE (High-tech Omics-based Patient Evaluation) uses next-generation DNA sequencing technology to bring about futuristic genetic medicine. By combining clinical information with the results of genetic analysis, our goal is to provide medicines customized for each patient - or in other words, personalized medicine based on the individual’s genetic information. This innovative model of medicine is expected in the near future.
The next-generation DNA sequencer analyses genetic information at ultra-highthroughput. To realize the full value of this system, we are working to develop an analysis system with much higher precision.
The development of fusion genes, resulting from translocation, interstitial deletion, or chromosomal inversion, is one of common characteristic of cancers. Although fusion genes are strong oncogenic genes, they can also be good targets for new
drugs. We are developing new screening methods for identifying fusion genes in cancers.
We are studying the linkage between personal diathesis and cancer development based on clinical information as well as genetic information. This genetic information includes also genetic variations in drug metabolic enzymes and impacts of smoking and drinking.
We are carrying out collaborative research with a local enterprise to develop equipment which will enable a multi-omics analysis to be conducted on a systematic process.
